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High Homocysteine Impact Osteoporotic Fractures

High homocysteine (HCY) levels are a risk factor for osteoporotic fracture. Furthermore, bone quality and strength are compromised by elevated HCY owing to its negative impact on collagen maturation. Click here to read more: Homocysteine-OsteoporoticFractures  

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Adrenal function an Introduction

Fatigue and lack of energy account for over 80% of adult health complaints. You may be suffering from adrenal fatigue, technically known as hypoadrenalism; Addison’s syndrome if you have any of the following: • ‘wake up tired in the morning’, • feel challenges bring fear or anxiety rather than confidence, • allergies that come on or get worse in adulthood, …

Proof That An Overburdened Immune System Is Root Cause Of Autoimmunity

Abstract Background: The cause of autoimmunity, which is unknown, is investigated from a different angle, i.e., the defect in immune ‘system’, to explain the cause of autoimmunity. Methodology/Principal Findings: Repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4+ T cells led to the development of autoantibody-inducing CD4+ T (aiCD4+ T) cell which had …

Urinary porphyrin excretion in neurotypical and autistic children.

Increased urinary concentrations of pentacarboxyl-, precopro- and copro-porphyrins have been associated with prolonged mercury (Hg) exposure in adults, and comparable increases have been attributed to Hg exposure in children with autism (AU). OBJECTIVES: This study was designed to measure and compare urinary porphyrin concentrations in neurotypical (NT) children and same-age children with autism, and to examine the association between porphyrin …

Disordered porphyrin metabolism: a potential biological marker for autism risk assessment.

Autism (AUT) is a complex neurodevelopmental disorder that, together with Asperger’s syndrome and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS), comprises the expanded classification of autistic spectrum disorder (ASD). The heterogeneity of ASD underlies the need to identify biomarkers or clinical features that can be employed to identify meaningful subtypes of ASD, define specific etiologies, and inform intervention and treatment options. …

Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children.

Mercury (Hg) is neurotoxic, and children may be particularly susceptible to this effect. A current major challenge is the identification of children who may be uniquely susceptible to Hg toxicity because of genetic disposition. We examined the hypothesis that CPOX4, a genetic variant of the heme pathway enzyme coproporphyrinogen oxidase (CPOX) that affects susceptibility to mercury toxicity in adults, also …

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Flavonoids linked to improved mental health

13/06/2007 – A diet rich in flavonoids, compounds in fruit, vegetables, coffee, tea and chocolate, could reduce the decline in mental function associated with age, says a new study from France. “This study raises the possibility that dietary flavonoid intake is associated with better cognitive evolution,” wrote lead author Luc Letenneur in the American Journal of Epidemiology.